Chronic hypoxia can be a troublemaker. It can cause cancer, hypertension, erectile dysfunction and dementia etc. on the opposite, intermittent hypoxia was considered a therapeutic impact on longevity. It can induce the regeneration process such as stem cell proliferation, migration, and differentiation. The critical point is the hormesis effect which means intermittent hypoxia can activate your gene or adapt your gene expression for a better life.